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Publications 2014

Animal studies

Nielsen MO, Khanal P, Johnsen L, Diaz G. Malnutrition during fetal life, fetal programming and implications for farm animal productivity. The VI International Conference on Agricultural Development and Sustainability. 2014.

Hou L, Hellgren LI, Kongsted AH, Vaag A, Nielsen MO. Pre-natal undernutrition  and post-natal overnutrition are associated with permanent changes in hepatic metabolism markers and fatty acid composition in sheep. Acta Physiol (Oxf). 2013 Dec 6. 210, 317-329. [Epub ahead of print]

Kongsted AH, Tygesen MP, Husted SV, Oliver MH, Tolver A, Christensen VG, Nielsen JH, Nielsen MO. Programming of glucose-insulin homeostasis: long-term consequences of pre-natal versus early post-natal nutrition insults. Evidence from a sheep model. Acta Physiol 2014 Jan;210(1):84-98. doi: 10.1111/apha.12080. Epub 2013 Mar 22.

Ingvorsen C, Thysen AH, Fernandez-Twinn DS, Nordby P, Nielsen KF, Ozanne SE, Brix S, et al. Effects of pregnancy on obesity-induced inflammation in  a mouse model of fetal programming. International Journal of Obesity 2014; 2014 May 2. [Epub ahead of print].

Khanal P, Husted SV, Axel AM, Johnsen L, Pedersen KL, Mortensen MS, Kongsted AH, Nielsen MO. Late gestation over- and undernutrition predispose for visceral adiposity in response to a post-natal obesogenic diet, but with differential impacts on glucose-insulin adaptations during fasting in lambs. Acta Physiol (Oxf). 2014 Jan;210(1):110-26. Epub 2013 Jun 25.

Kjaergaard M, Nilsson C, Rosendal A, Nielsen MO, Raun K. Maternal chocolate and sucrose soft drink intake induces hepatic steatosis in rat offspring associated with altered lipid gene expression profile. Acta Physiol (Oxf). 2014 Jan;210(1):142-53. Epub 2013 Jul 12.

Haque MN, Khanal K, Nielsen MO, Madsen J. Methane emission from artificially reared lambs and response to the fibrous diet. Proc. Conf. Livestock, Climate Change and Food Security, 19-20, May 2014, Madrid, Spain. P29 (abstract).

Martens GA, Motté E, Kramer G, Stangé G, Gaarn LW, Hellemans K, Nielsen JH, Aerts J, Ling Z, Pipeleers D. Functional characteristics of neonatal rat beta cells with distinct markers. J Mol Endocrinol 52:11-28, 2014.

Mortensen OH, Larsen LH, Orstrup LK, Hansen LH, Grunnet N, Quistorff B. Developmental programming by high fructose decreases phosphorylation efficiency in aging offspring brain mitochondria, correlating with enhanced UCP5 expression. J Cereb Blood Flow Metab. 2014 Apr 23.

Nielsen MO. Er der forskel på lammets liv før og efter fødslen – andet end de fysiske rammer? Får nr.3 2014 pp 6. Tidskrift for danske fåreavl (79) maj/juni. [Are there any difference between life before and after birth for the lamb – other than the physical conditions?], Tidsskriftet Får [ The Magazine Sheep] 79, 3, 6-9.

Khanal P, Pedersen KL, Pandey D, Safayi S, Nielsen MO. Late gestation malnutrition leads to similar impacts on adipose tissue distribution, development and function upon exposure to a postnatal high-fat diet in adolescent sheep. Proc Scand Physiol Soc Annual Meeting, Karolinska Institutet Campus, Stockholm August 22th – 24th, 2014. p51 (oral presentation).

Johnsen L, Axel A, Khanal P, Kongsted AH & Nielsen MO. Long-term implications of late-gestation malnutrition for the hypothalamic-pituitary- thyroidal axis in sheep. Proc. Scand Physiol Soc Meeting, Karolinska Institutet Campus, Stockholm August 22th – 24th, 2014. p50 (oral presentation).

Nielsen MO, Khanal P, Johnsen L, Kongsted AH. Foetal programming and long-term implications for metabolic and endocrine function. Book of Abstracts of the 65th Annual Meeting of the European Federation of Animal Science, 25-29 August, Copenhagen, Denmark. Wageningen Academic Publishers, The Netherlands. ISSN 1382-6077, p210. (invited oral presentation and session co-chair).

Gam CM, Mortensen OH, Qvortrup K, Damm P, Quistorff B. Effect of high-fat diet on rat myometrium during pregnancy-isolated myometrial mitochondria are not affected. Pflugers Arch. 2014 Aug 21. [Epub ahead of print]

Nielsen MO & Kiani A. Nutrient matabolisn in llamas: Not quite like in other ruminants. Vesterinärkongressen 2014. Uppsala 6-7 Nov.

Haque MN, Roggenbuck M, Khanal P, Nielsen MO, Madsen J. Development of methane emission from lambs fed milk replacer and cream for a prolonged period. Anim Feed Sci Technol. dec. 2014 (198) 38-48.

Khanal P, Axel AMD, Kongsted AH, Husted SV, Johnsen L, Pandey D, Pedersen KL, Birtwistle M, Markussen B, Kadarmideen HN, Nielsen MO. Late gestation under- and overnutrition have differential impacts when combined with a post-natal obesogenic diet on glucose–lactate–insulin adaptations during metabolic challenges in adolescent sheep. Acta Physiol DOI: 10.1111/apha.12391. 2014 

Birtwistle M, Khanal P, Kongsted AH, Nielsen MO, Budge H & Symonds ME. The impact of high energy intake during early postnatal life on gene markers for thermogenesis, adipogenesis and metabolism in the sternal and subcutaneous adipose tissue depots of sheep. Obesity – A physiological perspective, Physiol. Soc., September, Newcastle, UK. PC027. 1 p (abstract)

Birtwistle M, Khanal P, Kongsted AH, Nielsen MO, Budge H & Symonds ME. The impact of high energy intake during early postnatal life on gene markers for thermogenesis, adipogenesis and metabolism in the sternal and subcutaneous adipose tissue depots of sheep. Obesity – A physiological perspective, Physiol. Soc., 2014 September, Newcastle, UK. PC027. 1 p (abstract)

Nielsen JH, Haase TN, Jaksch C, Nalla A, Søstrup B, Nalla AA, Larsen L, Rasmussen M, Dalgaard LT, Gaarn LW, Thams P, Kofod H, Billestrup N: Impact of fetal and neonatal environment on beta cell function and development of diabetes. Acta Obstet Gynecol Scand. 93:1109-1122 (2014)

Nalla A, Ringholm L, Søstrup B, Højrup P, Thim L, Levery SB, Vakhrushev SY, Billestrup N, Mathiesen ER, Damm P, Nielsen JH. Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy. Acta Obstet Gynecol Scand. 93:1181-1189 (2014)

Søstrup B, Gaarn LW, Nalla A, Billestrup N, Nielsen JH. Co-ordinated regulation of neurogenin-3 expression in the maternal and fetal pancreas during pregnancy. Acta Obstet Gynecol Scand. 93:1190-1197 (2014)

Fløyel T, Brorsson C , Nielsen LB, Miani M, Bang-Berthelsen CH , Friedrichsen M , Overgaard AJ , Berchtold LA , Wiberg A, Poulsen P, Hansen L , Rosinger S , Boehm BO, Ram R , Nguyen, Mehta M, Morahan G, Concannon P, Bergholdt R, Nielsen JH , Reinheckel T, von Herrath M, Vaag A, Eizirik DL , Mortensen HB , Størling J , Pociot F. CTSH regulates β-cell function and disease progression in newly-diagnosed type 1 diabetes patients. Proc Nat Acad Sci US. 111:10305-10310 (2014)

Human physiological and clinical studies

Produced under network grant “Global maternal and fetal care in prevention of adult non-communicable disease” from the Danish Council for Strategic Research (no. 09-063072)

Danielsen I, Granström C, Rytter D, Halldorsson TI, Bech BH, Henriksen TB, Stehouwer CD, Schalkwijk CG, Vaag AA, Olsen SF. Subclinical inflammation during third trimester of pregnancy was not associated with markers of the metabolic syndrome in young adult offspring. Obesity (Silver Spring). 2014 May;22(5):1351-8. doi: 10.1002. Epub 2013 Dec 5

Jacobsen SC, Gillberg L, Bork-Jensen J, Ribel-Madsen R, Lara E, Calvanese V,Ling C, Fernandez AF, Fraga MF, Poulsen P, Brøns C, Vaag A. Young men with lowbirthweight exhibit decreased plasticity of genome-wide muscle DNA methylation byhigh-fat overfeeding. Diabetologia. 2014 Jun;57(6):1154-8. Epub 2014 Feb 26.

Mortensen B, Friedrichsen M, Andersen NR, Alibegovic AC, Højbjerre L, Sonne MP, Stallknecht B, Dela F, Wojtaszewski JF, Vaag A. Physical inactivity affects skeletal muscle insulin signaling in a birth weight-dependent manner. J Diabetes  Complications. 2014 Jan-Feb;28(1):71-8. Epub 2013 Oct 10.

Schultz NS, Broholm C, Gillberg L, Mortensen B, Jørgensen SW, Schultz HS, Scheele C, Wojtaszewski JF, Pedersen BK, Vaag A. Impaired leptin gene expression and release in cultured preadipocytes isolated from individuals born with low birth weight. Diabetes. 2014 Jan;63(1):111-21. Epub 2013 Sep 23.

Bao W, Bowers K, Tobias DK, Olsen SF, Chavarro J, Vaag A, Kiely M, Zhang C. Prepregnancy low-carbohydrate dietary pattern and risk of gestational diabetes mellitus: a prospective cohort study. Am J Clin Nutr. 2014 Jun;99(6):1378-84. doi: 10.3945. Epub 2014 Apr 9

Jacobsen SC, Gillberg L, Bork-Jensen J, Ribel-Madsen R, Lara E, Calvanese V, Ling C, Fernandez AF, Fraga MF, Poulsen P, Brøns C, Vaag A. Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding. Diabetologia. 2014 Jun;57(6):1154-8. doi: 10.1007/s00125-014-3198-8. Epub 2014 Feb 26.

Zhang C, Hu FB, Olsen SF, Vaag A, Gore-Langton R, Chavarro JE, Bao W, Yeung E, Bowers K, Grunnet LG, Sherman S, Kiely M, Strøm M, Hansen S, Liu A, Mills J, Fan R; DWH study team. Rationale, design, and method of the Diabetes & Women's Health study--a study of long-term health implications of glucose intolerance in pregnancy and their determinants. Acta Obstet Gynecol Scand. 2014 Nov;93(11):1123-30. doi: 10.1111/aogs.12425. Epub 2014 Jun 9

Bork-Jensen J, Thuesen AC, Bang-Bertelsen CH, Grunnet LG, Pociot F, Beck-Nielsen H, Ozanne SE, Poulsen P, Vaag A. Genetic versus Non-Genetic Regulation of miR-103, miR-143 and miR-483-3p Expression in Adipose Tissue and Their Metabolic Implications-A Twin Study. Genes (Basel). 2014 Jul 9;5(3):508-17. doi: 10.3390. 

Bao W, Tobias DK, Bowers K, Chavarro J, Vaag A, Grunnet LG, Strøm M, Mills J, Liu A, Kiely M, Zhang C. Physical activity and sedentary behaviors associated with risk of progression from gestational diabetes mellitus to type 2 diabetes mellitus: a prospective cohort study. JAMA Intern Med. 2014 Jul;174(7):1047-55. PubMed

Vaag A, Brøns C, Gillberg L, Hansen NS, Hjort L, Arora GP, Thomas N, Broholm C, Ribel-Madsen R, Grunnet LG. Genetic, nongenetic and epigenetic risk determinants in developmental programming of type 2 diabetes. Acta Obstet Gynecol Scand. 2014 Nov;93(11):1099-108. doi: 10.1111. Epub 2014 Sep 30.

Gillberg L, Jacobsen SC, Rönn T, Brøns C, Vaag A. PPARGC1A DNA methylation in subcutaneous adipose tissue in low birth weight subjects--impact of 5 days of high-fat overfeeding. Metabolism. 2014 Feb;63(2):263-71. doi: 10.1016. Epub 2013 Oct 23. 

Population-based studies

Leventakou V, Roumeliotaki T, Martinez D, Barros H, Brantsaeter AL, Casas M, Charles MA, Cordier S, Eggesbø M, van Eijsden M, Forastiere F, Gehring U, Govarts E, Halldórsson TI, Hanke W, Haugen M, Heppe DH, Heude B, Inskip HM, Jaddoe VW, Jansen M,Kelleher C, Meltzer HM, Merletti F, Moltó-Puigmartí C, Mommers M, Murcia M, Oliveira A, Olsen SF, Pele F, Polanska K, Porta D, Richiardi L, Robinson SM, Stigum H, Strøm M, Sunyer J, Thijs C, Viljoen K, Vrijkotte TG, Wijga AH, Kogevinas M, Vrijheid M, Chatzi L. Fish intake during pregnancy, fetal growth, and gestational length in 19 European birth cohort studies. Am J Clin Nutr. 2014 Mar;99(3):506-16.

Maslova E, Hansen S, Strøm M, Halldorsson TI, Olsen SF. Maternal intake of vitamins A, E and K in pregnancy and child allergic disease: a longitudinal study from the Danish National Birth Cohort. Br J Nutr. 2014 Mar;111(6):1096-108.

Strøm M, Hansen S, Olsen SF, Haug LS, Rantakokko P, Kiviranta H, Halldorsson TI. Persistent organic pollutants measured in maternal serum and offspring neurodevelopmental outcomes - a prospective study with 20 years follow up. Environment International. 2014 Jul; Vol 68. pp41-48. Epub 2014 Apr 2.

Rasmussen MA, Maslova E, Halldorsson TI, Olsen SF. Characterization of Dietary Patterns in the Danish National Birth Cohort in Relation to Preterm Birth. PLoS ONE 2014 Apr 18; 9(4): e93644.

Maslova E, Rytter D, Bech BH, Henriksen TB, Rasmussen MA, Olsen SF, Halldorsson TI. Maternal protein intake during pregnancy and offspring overweight 20 y later. Am J Clin Nutr. 2014 Aug 6. [Epub ahead of print]

Maslova E, Hansen S. Prenatal Dietary Determinants of Asthma and Related Allergic Disorders in Childhood. Current Nutrition Reports.Jun 2014,Volume 3, Issue 3, pp 233-244. September 2014.

Todberg T, Koch A, Andersson M, Olsen SF, Lous J, Homøe P. Incidence of otitis media in a contemporary Danish national birth cohort. PLOS ONE. 2014 okt. 7. [paper in press]

Hrolfsdottir L, Rytter D, Olsen SF, Bech BH, Maslova E, Henriksen T, Halldorsson TI. Gestational weight gain in normal weight women and offspring cardio-metabolic risk factors at 20 years of age. International Journal of Obesity. 9 October 2014.

Maslova E, Hansen S, Thorne-Lyman AL, Jensen CB, Strøm M, Cohen A, Nielsen NO, Olsen SF. Predicted vitamin D status in mid-pregnancy and child allergic disease.  Pediatr Allergy Immunol. 2014 Nov;25(7):706-13. Epub 2014 Dec 5. PMID: 25348236

Petersen SB, Olsen SF, Mølgaard C, Granström C, Cohen A, Vestergaard P, Strøm M. Maternal Vitamin D Status and Offspring Bone Fractures: Prospective Study over Two Decades in Aarhus City, Denmark. PLoS One. 2014 dec. 4; 9(12).

Last revised 11 September 2015